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Postdoctoral fellow: Development of statistical methodology for analysis of whole exome and genome sequences for complex disease

Postdoctoral fellow: Development of statistical methodology for analysis of whole exome and genome sequences for complex disease

Posted 4 February by AstraZeneca Featured Ended

Postdoctoral Fellow – statistical genomics of complex disease
Salary - competitive, plus excellent benefits

This is a 3-year, fixed-term contract based in Cambridge, UK with a competitive salary on offer.

A postdoctoral position is available in the AstraZeneca Centre for Genomics Research providing an exciting opportunity to use whole exome and whole genome data to identify causal genes involved in complex disease. The positions will be based at AstraZeneca’s new Headquarters at the centre of the Cambridge Biomedical Campus under the leadership of Dr Adam Platt, Global Portfolio lead of the Centre for Genomic Research, and advised by Professor David Goldstein, Director, Institute for Genomic Medicine & John E Borne Professor and Professor of Genetics and Development, Columbia University Medical Center, New York.

The successful applicant will have the opportunity to work with world leaders in the field to develop novel statistical approaches for the analysis of large genomic and phenotypic datasets. Candidates with an interest in intolerance scoring and signal detection theory to identify disease risk loci are particularly encouraged to apply.

The AstraZeneca Genomics Initiative aims to analyse data from up to 2 million genomes through a network of academic collaborations, including genomic samples donated by patients in its clinical trials. This genome sequence data is linked to rich phenotypic records including data on disease and drug response data. Focusing on AZ's core key therapeutic areas (oncology, respiratory, cardiovascular and metabolic disease), this initiative is expected to provide novel insights into the biology of disease, identify and validate new targets for medicines, improve selection of patients for clinical trials and match marketed treatments to patients most likely to benefit.

Using the power of genomics to better define disease supports our ambition to develop the most innovative and impactful treatments for patients. Genomics will be foundational to our research and development and help us in the discovery of the next wave of targeted innovative medicines.

For further details about our postdoctoral training programme please see: https://students/programmes/post-doctoral-programmes

AZ is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we are more than one of the world's leading pharmaceutical companies. At AZ, we are proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives – and are made to feel valued, energized and rewarded for their ideas and creativity.

Essential skill/capabilities:

  • A Ph.D. or equivalent qualification in a quantitative field such as Genetics, Statistics/Biostatistics, Epidemiology, Bioinformatics, Computer Science or other relevant discipline
  • A strong quantitative research background, statistical and programming proficiency, strong genetic knowledge
  • A demonstrated interest in using genetics to understand complex disease, leading to the discovery of new medicines
  • A strong background and understanding of Genetics, Genomics, Statistical Data Analysis
  • Proven communications skills, including writing of manuscripts and oral presentations
  • High capability to work in high performing teams


  • Experience in one or more of the following disease areas: oncology, respiratory, cardiovascular and metabolic disease
  • Practical experience of working with large-scale genetic data sets and producing high quality publications

To apply for this position, please click the apply below

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

Open date: 7th March 2017 / Closing Date:  6th April 2017

This is a 3-year, fixed-term contract based in Cambridge, UK with a competitive salary on offer.

If you share our passion for scientific excellence, find out more at

Reference: 31819898

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