Biotransformation Scientist

Do you have previous industrial experience in the area of drug discovery? Can you generate LC-HRMS metabolite profiling data from the analysis of in vitro & in vivo samples?

We are recruiting for a Biotransformation Scientist to work for our clients Biotransformation & Enzymology Group. You will be providing cross-project support across a range of new chemical entities from early stage hit identification through to pre & post-clinical evaluation.

As part of this team you will be a laboratory-based scientist with experience in the profiling of the biotransformation pathways of NCEs using LC-High Resolution Mass Spectrometry. Additional skills such as with other analytical techniques, in vitro methods and general lab skills would be advantageous. The successful candidate will enjoy a diverse and dynamic workflow supporting a number of projects.

This role is offered on a full time 12 month contract basis initially.

Responsibilities:

• Generate LC-HRMS metabolite profiling data from the analysis of in vitro & in vivo samples
• Efficiently generate, report and disseminate data to Biotransformation representatives
• Design and execute biotransformation-based assays to address key issues
• Take responsibility for the maintenance of LC-MS systems within the group
• Develop analytical methods for new chemical modalities

Qualifications / Experience:

• An experienced graduate or post-doctoral scientist (BSc. / MSc. / PhD) in chemistry or biochemistry
• Previous industrial experience in the area of drug discovery (3+ years)
• High resolution mass spectrometry and chromatography experience (HPLC, uHPLC, LC-HRMS) of small molecules
• An understanding of biotransformation pathways of NCEs
• Experience in general in vitro lab skills
• Be able to learn new laboratory skills quickly, demonstrate ability to follow protocols but also to design new experiments with excellent method development skills
• Autonomous, highly organised with excellent attention to detail
• Strong communication and a collaborative approach suited to a team working environment

Preferred requirements:

• Understanding of HRMS and MS fragmentation pathways for structural elucidation
• Understanding of metabolising systems and associated laboratory techniques
• Familiarity with Sciex and/or Thermo LCMS software, and any associated analytical or biotransformation related software
• Attention to detail and ability to follow protocols

In 2025, this site will relocate from Slough to Windlesham Surrey

Randstad CPE values diversity and promotes equality. No terminology in this advert is intended to discriminate against any of the protected characteristics that fall under the Equality Act 2010. We encourage and welcome applications from all sections of society and are more than happy to discuss reasonable adjustments and/or additional arrangements as required to support your application.

Candidates must be eligible to live and work in the UK.

For the purposes of the Conduct Regulations 2003, when advertising permanent vacancies we are acting as an Employment Agency, and when advertising temporary/contract vacancies we are acting as an Employment Business.