Associate Principal Scientist - Pharmacometrics

Are you a Pharmacometrics expert looking to make your mark across the pharmaceutical sector whilst working for a well renowned, exciting CDMO focused on solving complex pharmaceutical problems for their customers?

Job Title: Pharmacometrics Expert

Type: Permanent

Salary: Highly attractive

Location: Northwest, England

SRG is currently working exclusively with a highly successful, award winning, contract development and manufacturing organisation focused on providing expert intelligence and support to their partners, driven by their capabilities.

As a result of expansion and a significant increase in workload, we are looking for an expert in Pharmacometrics to join the Pharmacology team.

Typical responsibilities/accountabilities:

• Apply scientific and pragmatic design thinking to contribute to the delivery of candidate drugs and/or development plans, documentation, data interpretation and decisions for Clients' compounds and products as required (across the whole portfolio).
• Act as project leader for client projects, providing strategic and scientific PK/PD and biopharmaceutics advice across all stages of discovery and clinical development.
• Contribute to the design, analysis, and interpretation of non-clinical and clinical pharmacology studies.
• Conduct human PK and dose prediction through application of pharmacometric principles and analysis.
• Conduct PK/PD analysis and population PK and PBPK modelling and simulation.
• Author PK/PD sections of regulatory documents, including INDs, NDAs, briefing packets, Investigator Brochures, etc.
• Maintain current knowledge of advancements in DMPK and PK/PD science, regulatory guidance documents, FDA rulings, internal SOPs, and internal working practices to be able to contribute ideas to improve technologies and procedures for PK practice.
• Management of the financial aspects of projects with clients, such as costing proposals and invoicing.
• Represent at national and international meetings / conferences to build the reputation and awareness of the company
• Develop business development material such as white papers and technical communications for online posting and attend trade/partnering events

Essential Requirements:

• Educated to PhD and significant experience across pharmacometrics / pharmacokinetics / clinical pharmacology or Bachelors degree and significant industrial experience of leading.
• Deep expertise in PK/PD modelling with strong quantitative skills applied to develop models with nonlinear behaviour, mechanistic or semi-mechanistic components relating to mechanism of action and tailored to meet specific drug-development questions.
• You will be an expert in population Pharmacokinetic and Pharmacokinetic/ Pharmacodynamics modelling.
• Proficient in modelling (e.g., popPK and PK/PD analyses, model-based meta- analysis, dose-response and exposure-response analyses, dataset creation, disease modeling, trial simulation, optimal study designs, strategic decision analyses, economic modelling).
• Excellent technical and programming skills with population analysis and other software, including NONMEM and R as a minimum. Experience with Monolix and PKSim is a plus.
• Evidence of ability to develop drug products and documentation that meet clinical and regulatory requirements.
• Ability to apply scientifically sound principles efficiently in the analysis and interpretation of PK/PD data is a necessity.
• Valid UK driving license.

SRG are the UK number 1 recruitment company specialising in the science, engineering, clinical, pharmaceutical, food/FMCG, renewable, biotech, chemicals and medical devices sectors.

As scientists ourselves, our specialist sector knowledge and our passion are second to none. It's this combination that makes us different. We're committed to providing outstanding temporary, contract and permanent career opportunities of all levels for our candidates and a comprehensive range of expert strategic recruitment services for our clients.

If you would like to apply for this position, please use the link provided. Alternatively please email a copy of your CV to Usama at For more information regarding this position or any others, please call Usama on .

If you have a scientific background and this position is not relevant / suitable for you please feel free to get in touch or visit www.srg.co.uk to view our other vacancies.

Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.