Senior Scientist - AAV

Posted 23 February by Oxford Genetics Ltd

Oxford Genetics, a leader in synthetic biology, is a specialised contract research organisation offering services to support the discovery, development and production of biologics, with a particular focus on viral vectors for gene therapy applications. A unifying theme across the portfolio is expertise in DNA design, expression system optimisation, cell line development and engineering of viral delivery systems. We are located within purpose-fitted laboratories at the Oxford Science Park, just South of Oxford.

We are in a phase of rapid expansion and are seeking highly motivated and enthusiastic scientists, engineers and technicians to join the team and help facilitate the next stage of our development as a company. We aim to be both innovative and entrepreneurial in everything we do - join us and contribute to this exciting journey!

Role Overview:

The AAV Viral Vector Scientist will be involved in a range of internal platform development and commercial projects, predominantly focused on establishing novel AAV vectors, stable viral packaging cell lines and associated processes. Oxford Genetics has a number of on-going programmes and collaborations in this area, and multiple government supported grant awards, which the recipient will contribute towards. Scientist colleagues are expected to drive and lead specific projects and areas of research from the bench, while providing support and training to technicians working in the group. The position will involve extensive interaction with both internal and external stakeholders, and the ability to show commitment to scientific development and innovation are considered essential.

Key Responsibilities:

• Work closely with internal and external stakeholders to define project goals and deliverables, in line the planned project objectives
• To keep up-to date with the scientific literature and developments in the field
• Set an example to other colleagues, and to train junior staff in appropriate techniques
• Provide project summaries and reporting, as required
• Promote and suggest implementation of new methods, technologies and processes to ensure best practice
• Support line manager with customer interactions, and in ensuring smooth running of the group.
• To adhere strictly to established quality standards, essential for on-going activities
• Provide accurate record keeping at all times

• PhD/DPhil in relevant discipline, or MSc with extensive experience (more than 4 years)
• Experience working in a commercial/industry environment is preferred but not essential

• Extensive track record of handling a range of adherent and suspension mammalian cell lines
• High-level knowledge and experience of viral vector engineering, production and characterisation, with a focus on AAV
• Good experience with analytical techniques including flow cytometry and qPCR

• Production of stable mammalian cell lines
• Use of gene editing tools for cell engineering
• Experience of cell sorting, and characterisation of clonal cell lines
• Use of robotic liquid handling and automation systems

Job type: Permanent
Hours: Full time
Salary: £30,000 - £40,000 per annum, dependent on experience

Company Benefits:
25 days Annual Leave plus Bank Holidays, Pension with matched employer contribution to 7%, Health Insurance, Group Life Cover, Child Care Voucher Scheme, Glasses Vouchers and a friendly working environment in a small and expanding company.

Job Location:
We have offices in the UK and USA. This role will be located at The Oxford Science Park, just 4 miles south east of Oxford, with parking and good public transport links from Oxford.

How to apply:

Candidates must be eligible to work in the United Kingdom without sponsorship.

Please apply online with your CV and covering letter. Your CV should include evidence that demonstrates how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks. Your application will be judged on the basis of how you demonstrate that you meet the selection criteria stated in the job description.

Diversity and Equality of Opportunity:

We provide all our staff with a welcoming and inclusive workplace that enables and empowers everyone to develop and deliver professional excellence. We recognise diversity is vital for innovation and creativity and value each individual’s contribution. Entry into employment with Oxford Genetics and further progression will be determined by personal merit and the application of criteria related to the duties of the role. The ability to perform the role will be the primary consideration on entry into employment and to successfully pass probation.

Pre Employment Screening:

The appointment of the successful candidate will be subject to standard pre-employment screening, as applicable to the post. This will include right-to-work in the UK, proof of identity, references and health assessment.

Please check your email for confirmation that your application has been received and to follow further instructions if applicable.

Reference: 34540903

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