Research Scientist (Home Office Licence In Vivo, Cell Culture, Oncology)
£30k - £35k + benefits
Our client is developing a new generation of ultrasound-based medical devices for drug delivery and surgical applications and providing on-screen feedback to the clinician as to where drug delivery or surgery is taking place in real time.
They now have a requirement for a Research Assistant scientist responsible for supporting the in vitro and in vivo research of the company’s drug delivery technology platform as part of the small Development team.
It is essential that applicants have a current Home Office personal licence modules 1 - 3 also mammalian cell culture experience, a working knowledge of some of qPCR, ELISA, IHC and flow-cytometry analysis, be graduate level and with some oncology background.
Studies to assess the benefit of a range of therapeutic agents in a variety of tumour types.
In vivo studies of drug delivery and efficacy
- Home Office licensed procedures
- Working with syngeneic and xenograft murine tumour models and sub-cutaneous, intra-peritoneal and intravenous delivery methods
- Tumour measuring and monitoring the condition of animals, recognising and resolving any problems.
- Ensure compliance with Home Office licence and adherence to company protocols and study plans.
in vitro and ex vivo activities
- Tissue culture such as cell preparation for in vivo experiments, in vitro drug sensitivity studies.
- Analysis of ex vivo samples involving assays such as qPCR, ELISA, flow-cytometry.
- Keep full and accurate experimental records according to company quality standards and Home Office regulations.
- Willingness to learn new techniques
- Contributing to the running of the lab (e.g. consumables ordering, equipment maintenance, cleaning)
- Perform in vivo regulated procedures according to project licence and Home Office regulations, such as as sub-cutaneous, intra-peritoneal and intravenous injections in mice.
- Perform standard cell biology techniques, such as cell culture and plate reader-based assays.
- Take a flexible approach to work and perform tasks outside of one’s job description.
- Be able to operate as a self-starter and to work both independently as well as a part of a team.
- Apply excellent organizational skills.
- Work to the highest quality standards and with attention to details
- Use Microsoft Office software.
- Work with xenografts and syngeneic murine tumour models
- Work safely and effectively with a variety of cancer treatment such as small molecule drugs, antibodies and viruses.
- Perform nucleic acid analysis such as qPCR (including DNA and/or RNA extraction).
- Analyse protein expression with different analytical approaches such as ELISA and flow-cytometry.
Training will be provided where necessary
- A current Home Office personal licence modules 1 - 3.
- An academic degree in a relevant scientific discipline.
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