With experience of cellular and biochemical assay development you will be working within a multidisciplinary team investigating the molecular and cellular mechanisms underlying human neurodegenerative diseases, in particular Alzheimer's disease and Parkinson's disease.
To explore in vitro and ex-vivo the cellular and molecular mechanisms of chronic pain, with an emphasis on neuroinflammation and on translational science (rodent versus human).
Provide problem solving, technical leadership, and planning for level 1 staff and students within technical area.
The main responsibilities of this role will be to:
- Isolate various native cell types (with a focus on neurons, glial and immune cells) and culture them in vitro. Maintain and culture cell lines (including iPSC-derived).
- Isolate and characterize subcellular structures and various types of secretory vesicles.
- Use isolated cells or brain/spinal slice to study protein expression and biochemical modifications, receptors and second messenger modulation, ion channels function, cytokines and neurotransmitter release, calcium imaging and intrinsic excitability (single cell and population level).
- Accurate analysis of biochemical, physiological and electrophysiological data sets.
- Novel assay development and technical problem solving.
- Accurate recording of all practical work: completion of electronic lab notebook to Lilly procedure quality standards.
- Maintaining a tidy and efficient laboratory environment and ensuring health and safety standards are met.
You are required to have the following qualifications, skills and experience:
- Ph.D. in neuroscience-relevant subject (e.g. biochemistry, neuroscience, physiology).
- Working knowledge and routine following of key pain-related literature, encompassing biochemistry, neurobiology, and neurophysiology.
- Sound knowledge of experimental design and statistics for biology experimental work.
- Ability to write sound reports, posters and papers.
- Understanding of biology lab safety requirements.
- Strong organisation skills, good time management and attention to detail.
- Ability to analyse and interpret experimental data, identify errors and plan future work accordingly.
- Report results accurately and in a timely manner.
- Ability to communicate effectively with supervisor and larger team.
- Mentorship and technical supervision of junior staff within technical area.
- Respect for people and diversity.
Our client has 7,000 employees who work just within the Research Laboratories, spanning more than 50 countries worldwide and are the 7th largest investor in R&D in the UK within the pharmaceutical sector. The successful candidate will be a full time fixed term employee of the CK Group and will be working for CK as part of a very busy, productive team of scientists that CK provide for our client as an outsourced function. As such they must be able to demonstrate enthusiasm, dedication and self-motivation together with the desire to acquire new skills.
Please note that your CV should show exact dates of employment (month and year) and any gaps of a month or more should be explained.
CK Group is an Equal Opportunities employer and welcomes applications from all who meet our selection criteria.
If you do not hear back from us within 5 working days of your application for this role, it means that on this occasion you have not been shortlisted for the next stage of the recruitment campaign. Entitlement to work in the EEA is essential. Please quote reference 46457 in all correspondence.
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