There is now an opportunity for an expert in development of complex disease-relevant cell models to join our research team.
This collaborative individual will establish complex cellular models relevant to disease, using patient-derived cells and tissues, iPS cells, and complex 3D and co-culture systems. They will establish human models of disease, consider opportunities to model the diversity of patients through suites of iPS lines, and consider opportunities for co-culture systems to improve understanding of compound activity and predictivity to disease. They will utilise these models in collaborative projects to validate targets and to advance technologies for the analysis of complex cell biology including mass spectrometry and molecular profiling. They will be familiar with developing and validating novel cell models of disease. They will have expertise in cell culture of primary cell lines, iPS and patient derived lines, organoids and/or co-culture systems, and some experience in innovative design of cell assays. They will develop and optimise new commercial products, and collaborate closely with our partners in academic and industrial labs.
The successful candidate will have extensive knowledge of innovation in cell biology and in advanced cell culture, and will be able to demonstrate expertise in generation of high quality data across a range of relevant assay platforms. They will be able to establish external collaborations to advance internal capability and to access cells and tissues.
This role would suit a highly motivated self-starter, who are keen to further develop their skills, is collaboratively minded, deadline driven and well organised. The opportunity to join a world class laboratory team in this high profile national organisation should provide a fantastic platform to further develop your career.
Main Duties and Responsibilities:
- Establish stem-cell-derived culture systems modelling disease biology.
- Establish relationships with tissue banks and experts in universities and other organisations.
- Establish patient tissue-derived cell models.
- Establish complex 3D, organoid and/or co-culture systems to ensure cell-based assay data that is predictive of disease exploiting the latest in readout technologies eg. 'omics.
- Strategic insight into high-impact collaborative projects with potential for commercial impact.
- Analysis skills and technology development to improve assays and advance new approaches.
- Deliver high quality data in a complex and time pressured research team environment.
- Manage complex collaborative projects with external partners to completion.
- Contribute scientific insight, innovative assays, to advance technologies.
- Effective communication and research collaboration skills, working with a wide range of colleagues in range of academic and commercial organisations
Qualifications and Experience :
- The successful candidates will possess a degree and/or PhD in a Biological discipline, along with substantial relevant experience.
- Extensive cell biology expertise and proven understanding of disease models, is required.
- Extensive experience across a range of assay platforms, and of cell culture.
- Demonstrable impact on disease biology understanding and/or of leading drug discovery programmes
- Depth of knowledge of one or more disease areas, with preference for inflammation, neuroscience, or cardiovascular.
Equal Opportunities Statement
Medicines Discovery Catapult is an equal opportunities employer that recognises the value of a diverse workforce. Medicines Discovery Catapult will welcome applications from all suitably qualified applicants regardless of disability, sex, sexual orientation, gender reassignment status, marital or civil partnership status, race, religion/belief or age.
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