Drug delivery scientists - formulation/analytical

Posted 4 days ago by AstraZeneca

Drug Delivery Scientists – Formulation/Analytical

Cambridge UK, Gothenburg Sweden

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans traditional small molecules, peptides, oligonucleotides to RNA based therapeutics across AstraZeneca’s therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to provide novel products to AstraZeneca’s clinical pipeline.

We are now looking for drug delivery scientistswith strong expertise in the formulation and analytical sciences to work on delivering new modalities for gene therapy.

In this role you will be responsible for design and characterisation of formulations for the delivery of nucleic acids. This will involve working with advanced drug delivery platforms such as lipid nanoparticles. Working in close collaboration with peers in the advanced drug delivery group, you will continually be improving our end to end formulation design, characterisation and testing capabilities. As part of the team you will serve on global drug project teams working with scientists across UK, US and Sweden. You will also be expected to drive science networks and provide high quality scientific input across the organisation.

You will be involved in establishing and driving close research collaborations across academia and small biotech companies. We expect you to be an active member of the external scientific community enhancing our reputation as scientific leaders in the advanced drug delivery field.

We are seeking ambitious scientists with a strong foundation in the delivery sciences and a specialisation in the formulation and analytical sciences as well as a great passion for experimental science. This is a hands-on, lab-based position where you will work with different teams, so you should like communicating and have the capacity to share your data.

If you are committed to developing your career in the pharmaceutical sciences – this might be the role for you!

The location for these positions are flexible between Cambridge, UK and Gothenburg, Sweden.

Essential Requirements
  • PhD or Master’s degree in pharmaceutical sciences, biology, chemistry or a related discipline

  • Experience of formulating colloidal products such as lipid nanoparticles, polymeric delivery vehicles, other nanoparticle technologies, injectables or emulsions.

  • Strong technical knowledge of nucleic-acid based drug delivery technologies

  • Experience in analytical instrumentations used in formulation characterization (particle size and zeta potential measurements, pKa determination etc.)

  • Strong record of scientific excellence evidenced by publications, patents and presentations

  • Thorough understanding of principles, applications and management of Safety Health and Environment (SHE)

Desirable Requirements
  • Practical skills for the design and synthesis and purification of new materials to support nucleic acid delivery efforts

  • Practical skills with cell based and in vivo assays to assess the performance of nanomedicines

  • Experience working with nanomedicines and experience formulating intracellular delivery systems for nucleotides and/or proteins

  • A working knowledge of CRISPR-related biology and a good knowledge of endosomal biology

Are you ready to make a difference? Send in your application, and we’ll make it happen together.

Application Open 18/05/2020

Application Close 19/06/2020

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

Reference: 40422434

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