ANALYTICAL METHOD DEVELOPMENT SCIENTIST - WILTSHIRE

Posted 28 September by Bosch Global Associates Ltd

Location: Wiltshire

Dept.: Protein Analysis.

Salary: Up to £32k

Training: Yes (Full).

Type: Permanent position.

SUMMARY:

We are looking for someone with education to at least degree level in a relevant subject is essential, as is hands-on experience of developing and validating protein analysis methods, ideally in a biopharmaceutical setting.

Candidates must be familiar with a broad range of protein sample preparation and analytical methods, preferably with involvement in their development, optimisation, validation and implementation.

Examples of relevant techniques are: immunoassays; 2D-gel electrophoresis; enzyme activity assays; HPLC, UPLC and 2D-gel chromatography; sample concentration methods; release methods for vaccine formulations.

Experience of preparing technical documentation such as standard operating procedures, protocols and reports is required.

The successful candidate will also be expected to maintain up-to-date knowledge of ICH guidelines and other regulatory guidance relating to analytical methods.

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MAIN DUTIES AND RESPONSIBILITIES:

  • Leading the development of methods for the analysis of biopharmaceuticals from feasibility, through method development and validation, to routine use within the Development group and/or transfer to QC.
  • Undertaking projects ensuring appropriate methods, assays, techniques and systems are implemented and utilised to meet project targets.
  • Taking responsibility for the provision of reagents and consumables required for the project and for documented storage of materials generated.
  • Assisting in identifying, evaluating and adapting new technologies where appropriate and helping to ensure that projects operate to a high scientific standard.
  • Establishing links and collaborations within and outside as necessary to benefit the project and/or department.
  • Assisting senior colleagues in developing scientific and technical strategy.
  • Identifying new opportunities as they arise.
  • Taking responsibility for the supervision and training of junior staff where appropriate.
  • Providing study protocols and reports as required.
  • Performing any other duties required by the Line Manager commensurate with grade.
  • Ensuring that work is undertaken in accordance with Porton Biopharma’s Code of Safety Practice and relevant quality standards.
  • Maintaining awareness of Industry and International Regulatory Standards and guidance and implementing where appropriate.

REQUIREMENTS:

  • Degree in Biological Science or Chemistry.
  • Hands-on experience of developing and validating protein analysis methods.
  • Experience of developing and validating protein analysis methods in a biopharmaceutical setting.
  • Experience of a broad range of protein sample preparation and analytical methods.
  • Wide-ranging experience of general biochemical and/or molecular biology techniques.
  • Experience of developing, optimising, validating and/or implementing:

Immunoassays;

2D-gel electrophoresis;

HPLC, UPLC, 2D-gel chromatography, Etc.;

KEYWORDS:

PORTON DOWN / WILTSHIRE / SALISBURY / BASINGSTOKE / BRISTOL / OXFORD / HAMPSHIRE / BIOLOGICAL SCIENCE / CHEMISTRY / PHARMACEUTICAL / PHARMA / GMP / DRUG / BIOPHARM / BIOPHARMACEUTICAL / ASSAY DEVELOPMENT / ANALYTICAL / VALIDATION / SCIENTIFIC / SCIENTIST / METHOD DEVELOPMENT SCIENTIST / PHARMACEUTICAL PRODUCTION / PROCESS DEVELOPMENT / ANALYTICAL DEVELOPMENT / QUALITY CONTROL / QUALITY ASSURANCE / HPLC / UPLC / PROTEINS / SUPERVISOR / TECHNICAL FILES / TECHNICAL DOCUMENTATION / ICH GUIDELINES / US FEDERAL CODES / cGMPs / METHODS / ESSAYS / TECHNIQUES / SYSTEMS / CONSUMABLES / VALIDATING / EVALUATING / TECHNOLOGIES / CHEMIST / CHEMISTRY / BIOLOGICAL / BIOCHEMICAL / OFFICER.

Required skills

  • Assay Development
  • Biological
  • Chemistry
  • GMP
  • Pharmaceutical

Application question

Do you have at least 5 years expertise in of developing and validating protein analysis methods?

Reference: 32761366

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